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ASP Scan (Weekly) for Dec 20, 2019

first_imgOur weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scansBioMerieux tapped to provide diagnostics in LMICs to combat AMROriginally published by CIDRAP News Dec 19Yesterday, French diagnostics company bioMerieux announced that that the Fleming Fund has selected it as a supplier in a tender process to tackle antimicrobial resistance (AMR) in 18 low- and middle-income countries.The Fleming Fund is investing £265 million ($345 million US) in the process, which will involve equipping one reference clinical lab and one veterinary lab in 18 countries across Africa and the Asia-Pacific with diagnostic, susceptibility, and data processing technology over the next 3 years, according to a bioMerieux news release.”It is a pleasure to work in partnership with bioMerieux to help strengthen health systems and contribute to tackling the threat of antimicrobial resistance around the world,” said Andy Leigh, a Fleming Fund program director.BioMerieux will be active in 18 out of the 24 countries taking part in the program. The company will equip labs with its Vitek MS and Vitek 2 systems for pathogen identification and antimicrobial susceptibility testing, and with Myla software for data processing. Dec 18 bioMerieux news release French stewardship study finds benefits from combined strategiesOriginally published by CIDRAP News Dec 19A study in France has found that the combination of simplified therapeutic guidelines (STGs) and accompanied self-antibiotic reassessment (ASAR) was associated with optimal antibiotic therapy and reduced antibiotic use at 15 hospitals, researchers reported yesterday in the Journal of Antimicrobial Chemotherapy.The STGs resulted from at least two rounds of antibiotic audit and feedback at the 15 hospitals and were based on national and international guidelines, the medical and surgical activities of every institution, and on data regarding resistant bacteria. The STGs were explained to prescribers in ASAR sessions, which typically lasted 45 to 90 minutes and consisted of reviewing four to six patients’ files. To measure the impact of these strategies, the researchers reviewed patients receiving antibiotic therapy and rated the quality of the antibiotic treatment before and after implementation. They also measured antibiotic consumption at the hospitals, focusing on amoxicillin/clavulanic acid, third-generation cephalosporins, and fluoroquinolones.Comparison of prescriptions in five hospitals before and after implementation of STGs and ASAR showed that these tools were associated with optimal therapies (adjusted odds ratio [AOR], 3.28; 95% confidence interval [CI], 1.82 to 5.92), amoxicillin/clavulanic acid prescriptions (AOR, 2.18; 95% CI, 1.38 to 3.44) and fewer prescriptions for urine colonization (AOR, 0.20; 95% CI, 0.06 to 0.61). Comparison of prescriptions from 10 departments of three hospitals with STGs and ASAR for the first quarters of 2018 and 2019 revealed that the prescriptions by 23 ASAR participants more often complied with STGs than those by 28 other physicians (71% vs 60%; P = 0.003).Comparing prescriptions in the 10 hospitals that adopted STGs alone with prescriptions at the 5 hospitals that adopted both tools, the researchers observed fewer unnecessary prescriptions in the latter (AOR, 0.52; 95% CI, 0.34 to 0.80). The variation in critical antibiotic consumption between 2017 and 2018 was -16% for the 5 hospitals that adopted both tools and +20% for the other 10.”In conclusion, STGs + ASAR is a combination of tools that increase the efficiency of non-specialized prescribers, leading to an increase in optimal antibiotic therapy and a reduction in antibiotic consumption,” the authors of the study write. “As these tools do not require financial support, our results would be helpful for low- and middle-income countries.”Dec 18 J Antimicrob Chemother abstract Contact with puppies tied to MDR Campylobacter in 13 statesOriginally published by CIDRAP News Dec 18Puppies from Petland pet stores are again implicated in a multistate outbreak of multidrug-resistant (MDR) Campylobacter infections, this time affecting at least 30 people in 13 states, the Centers for Disease Control and Prevention (CDC) said yesterday in an update.Four people have been hospitalized in this outbreak, caused by Campylobacter jejuni, but none have died. “Epidemiologic and laboratory evidence indicate that contact with puppies, especially those at pet stores, is the likely source of this outbreak,” the CDC said. The agency added, “Laboratory evidence indicates that bacteria from ill people in this outbreak are closely related genetically to bacteria from ill people in the 2016–2018 outbreak of multidrug-resistant Campylobacter infections linked to pet store puppies.”In both the current and earlier outbreaks, the CDC named Petland stores as a likely source of the contaminated puppies. Of 15 people in the current outbreak who reported contact with a puppy from a pet store, 12 (80%) were linked to Petland, including 5 employees.The 2016-18 MDR Campylobacter outbreak involved 113 cases and 23 hospitalizations in 17 states. The CDC posted its final outbreak notice on that event on Jan 30, 2018.Illnesses in this year’s outbreak began from Jan 6 to Nov 10, with patients ranging from 8 months to 70 years. Whole-genome sequencing of 26 isolates from patients predicted antibiotic resistance to tetracycline (26 isolates), ciprofloxacin (25), nalidixic acid (25), azithromycin (23), erythromycin (23), clindamycin (23), telithromycin (23), and gentamicin (18).Dec 17 CDC statement Jan 30, 2018, CDC final notice on previous outbreak ECDC details CRE outbreak in Lithuanian hospitalsOriginally published by CIDRAP News Dec 18The European Centre for Disease Prevention and Control (ECDC) today issued a report on an outbreak of Klebsiella pneumoniae carbapenemase-producing carbapenem-resistant Enterobacteriaceae (KPC-CRE) in Lithuania.According to the ECDC’s rapid risk assessment, 199 KPC-CRE cases were detected from Feb 1 through Nov 26, with 186 cases (93%) occurring in a single hospital (hospital 1). The cases include infections as well as carriage, and most of the isolates were Klebsiella pneumoniae (186 cases, 93%), followed by Escherichia coli (16 cases, 8%), Citrobacter freundii (2 cases), and Enterobacter aerogenese (1 case). In all isolates, carbapenem resistance was mediated by the KPC enzyme. Additional resistance to colistin was detected in 26 of 52 isolates tested.The outbreak was first identified in April 2019, with the first case detected in a patient with a surgical-site infection admitted to the intensive care unit of hospital 1, and was still ongoing as of Dec 11.”The risk of further spread of CRE in the most-affected hospital is high, as a large number of cases have been identified from multiple wards and new cases continue to be detected at the time of this risk assessment,” the report says. “While enhanced infection control measures have been implemented, the outbreak appears not yet to have been controlled.”Six additional hospitals have also reported KPC-CRE cases, and the ECDC says the risk of further spread in the Lithuanian health system is high, since screening for CRE carriage was not in place in Lithuanian hospitals before December 2019. Lithuania reported only 5 and 12 cases of CRE in 2017 and 2018, respectively.The ECDC says screening of patients at high risk for digestive tract carriage of CRE due to healthcare contact in the preceding 12 month, along with pre-emptive contact precautions and isolation, should be considered. Further epidemiologic investigations are ongoing.Dec 18 ECDC rapid risk assessment Resistant E coli intestinal carriage found in VA patients, housematesOriginally published by CIDRAP News Dec 18Veterans Affairs (VA) patients and members of their household commonly carry and share a strain of multidrug-resistant E coli that’s emerged as a common source of extra-intestinal infections in hospitals, researchers from the University of Minnesota and the Minneapolis VA Medical Center reported today in the Journal of Infectious Diseases.For the study, the researchers screened fecal samples from 741 volunteers (383 VA patients and 358 household members, including pets) for fluoroquinolone-resistant E coli (FQREC) and E coli sequence type (ST) 131. They were specifically interested in the H30 subclone within ST131, and its fluoroquinolone-resistant H30R subset, both of which have expanded rapidly in recent years. Because these extra-intestinal pathogenic E coli strains usually originate in patients’ gut microbiota before causing extra-intestinal infections, it’s been theorized that widespread gut colonization could underlie epidemic clonal emergence.The results showed that colonization prevalence was 5.1% for H30R, 8% for ST131 (67% FQREC), and 10% for FQREC (52% ST131). Among the 425 strains that underwent virulence genotyping, ST131 isolates exhibited more virulence genes than non-ST131 isolates. Strain sharing appeared in 27% of the 100 assessed multi-subject households and 18% of corresponding subjects, and was associated with the elderly, FQREC, H30R, H30Rx, E coli ST73, and specific virulence genes. Comparison of fecal ST131 and FQREC isolates with a collection of clinical E coli isolates from Minneapolis VA patients found similarities in virulence gene content, resistance profiles, and other traits, a finding that supports the idea that the clinical strains emerge from the gut reservoir.”In conclusion, as an intestinal colonizer of uninfected veterans and their human household members, H30R was much more prevalent than any other FQREC strain, largely independent of the studied host characteristics,” the authors of the study write.”Comparative prevalence values suggested that, relative to other FQREC, H30R is likely both a better gut colonizer and more capable of causing infections in colonized hosts, phenotypes possibly promoted by H30R’s extensive repertoire of virulence factors, which may also represent colonization factors. Thus, colonization fitness, virulence, and within-household strain sharing may all underlie H30R’s epidemic success, and could be targets for preventive interventions.”Dec 18 J Infect Dis abstract BARDA to fund development of antibiotics for resistant gram-negativesOriginally published by CIDRAP News Dec 16San Diego-based biopharmaceutical company Qpex Biopharma today announced it will receive a second round of funding from the Biomedical Advanced Research and Development Authority (BARDA) to develop a portfolio of antibiotics targeting antibiotic-resistant gram-negative bacteria.Under the Other Transaction Authority (OTA) agreement with BARDA, Qpex will receive $20 million to advance three products into clinical studies: ORAvanceTM, an orally administered beta-lactamase inhibitor (BLI)-based product for treating infections caused by extended-spectrum beta-lactamase (ESBL)- and carbapenemase-producing Enterobacteriaceae; OMNIvanceTM, an intravenous (IV) BLI-based product; and QPX9003, a next-generation IV-administered polymyxin designed to address highly-resistant Pseudomonas and Acinetobacter infections.The $20 million option is the second award under the OTA agreement, which provides for up to $132 million in funding.”We are grateful for our successful and longstanding partnership with BARDA, whose commitment to address the global and growing threat of antimicrobial resistance has been unparalleled,” Qpex Biopharma President and CEO Michael Dudley, PharmD, said in a company press release. “Our team has made rapid progress since forming the company just over a year ago, and the continued support from BARDA puts us in a strong position as we transition to a clinical-stage company.”Dec 16 Qpex Biopharma press release WHO announces updates to drug-resistant TB treatmentOriginally published by CIDRAP News Dec 16The World Health Organization (WHO) last week issued a rapid communication outlining updated treatment recommendations for patients with drug-resistant tuberculosis (TB), based on evidence reviewed in a November meeting of its Guideline Development Group (GDG).The main change suggested by the GDG is the introduction of a shorter, all-oral, bedaquiline-containing drug regimen for patients with multidrug-resistant and rifampicin-resistant tuberculosis (MDR/RR-TB) that would replace shorter regimens with injectables. The recommendation is based on analysis of data from a South African TB program that showed that replacing the injectable with bedaquiline resulted in significantly better treatment success and a considerable reduction in loss-to-follow up in MDR/RR-TB patients who had no previous exposure to second-line drugs, confirmed fluoroquinolone-susceptibility, and no extensive disease or severe extrapulmonary TB.The group also recommended that in certain patients with extensively drug-resistant TB (XDR-TB), the novel 6- to 9-month bedaquiline, pretomanid, and linezolid (BPaL) regimen may be used under operational research conditions as an alternative to the standard, 18-to-24 month regimen. That recommendation is based on results from the phase 3 Nix-TB trial, in which the BPaL regimen showed high treatment success in 108 South African XDR-TB patients. But the WHO says that the regimen may not considered for programmatic use worldwide until additional safety and efficacy evidence has been generated.The communication was released to inform national TB programs in advance of the WHO’s updated guidelines on drug-resistant TB treatment, which are expected to be published in 2020.Dec 11 WHO rapid communication FDA clears disposable duodenoscopeOriginally published by CIDRAP News Dec 16The US Food and Drug Administration (FDA) recently announced that it has cleared the first fully disposable duodenoscope, which is designed to reduce the risk of infection due to difficulties sterilizing the devices.Duodenoscopes are threaded through a patient’s mouth into the top of the small intestine and are used to visualize the upper gastrointestinal tract, and they provide a less invasive way to treat some problems, such as removing pancreatic and biliary duct blockages. However, the devices have many small parts, making them difficult to clean. Some models have been linked to a number of outbreaks involving multidrug-resistant bacteria in US and European hospitals.The disposable model, called the EXALT Model D single-use duodenoscope, is made by Boston Scientific Corp. In a Dec 13 statement, the company said the device is made for use in endoscopic retrograde cholangiopancreatography procedures (ERCP), and the FDA had granted it breakthrough device designation. Each year, more than 1.5 million ERCPs are performed in the world, according to the company, which added that it plans to start selling the device on a limited basis during the first quarter of 2020.Jeff Shuren, MD, JD, who directs the FDA Center for Devices and Radiological Health, said in the FDA statement, “The availability of a fully disposable duodenoscope represents another major step forward for improving the safety of these devices, which are used in more than 500,000 procedures in the U.S. each year.”The new approval comes about a month after the FDA approved a new type of duodenoscope with fewer parts needing disinfection.Dec 13 FDA statement Dec 13 Boston Scientific press release Nov 18 CIDRAP News scan “FDA clears duodenoscope with fewer parts needing disinfection”last_img read more

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UK & European buys Kingsway Estate for £52m

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Aberdeen defies crunch

first_imgGerman fund manager Pramerica has gone under offer to buy bp’s Aberdeen headquarters for just under the £54m asking price.The 207,000 sq ft building has been sold by Goodman at around a 6.25% yield.According to research by Knight Frank, Aberdeen, which is the UK home for the oil industry, has been insulated from the global credit crunch with record levels of rental growth, longer lease terms and fewer break options.Cushman & wakefield advised Pramerica; Strutt & Parker’s London office advised Goodman.last_img read more

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Springfield secures green light for new affordable Fife scheme

first_imgSpringfield’s new Ballingry SiteThe plans include a mix of two and three bedroom bungalows, terraced and semi-detached homes on the site of the former Kirkland Farm land. The new homes will sit between the memorial gardens and Ballingry Meadow Wildlife site which will be linked to the development by footpaths and informal tracks.The scheme will be Springfield’s first in the region and follows last month’s acquisition of fellow housebuilder Dawn Homes for £20.1m.Group partnerships managing director Tom Leggeat said: “To have been granted planning consent in an area where we haven’t built before is great news. We’ll be building a mix of affordable houses and bungalows with our established and local partner, Kingdom Housing Association.“The development is open and spacious with green areas for children to play. The homes will be energy efficient too meaning reduced running costs for the tenants. The construction of the new homes will bring jobs to Ballingry, which will in turn support the local economy. We are looking forward to making a start on site in the coming months.”Springfield posted its maiden interim results showing a 10.5% rise in revenue, and a 19.6% leap in adjusted pre-tax profit, in February of this year.last_img read more

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Aqua Lung divestment in “exclusive negotiation” phase

first_imgGet instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270. Subscribelast_img

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CCS market to cross $6bn by 2026

first_imgThat’s according to a recent study by Global Market Insights, a market and strategy consulting firm who says the demand for CCS projects is “flourishing”.Global Market Insights has said that stringent government regulations towards curtailing greenhouse gas emissions, along with rising demand for CCS technologies to minimise carbon footprints, will propel the industry.The report released earlier this week predicts that Europe’s CCS market will grow over 10% by 2026, primarily driven by government efforts to deploy emission control technology such as CCS.Additional key findings from the report include:The flourishing demand for CCS projects across the industrial sector due to longer operating life and emission control nature.Growing investments across various industries, including chemical, oil & gas, and power generation, driving industry growth.Major players such as Mitsubishi Heavy Industries, Japan CCS Co., Ltd, Shell Cansolv, Fluor Corporation, Siemens, Schlumberger Limited, Halliburton are now operating in the CCS market.Acceleration of technology trends expected due to positive outlook toward the expansion industries, along with stringent government norms to diminish CO2 emission.last_img read more

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Lady Gaga, Bruno Mars, Sting set for American Music Awards

first_img Author: AP Published: November 20, 2016 10:52 AM EST Do you see a typo or an error? Let us know. (AP) — With new albums to promote, the timing is perfect for Sunday’s American Music Awards, where performers include top pop stars such as Lady Gaga, Bruno Mars and The Weeknd.Mars released his new album, “24K Magic,” on Friday, and a day after Thanksgiving, the Weeknd will drop “Starboy.” Gaga released “Joanne” last month.Other big-named acts who recently released albums will also perform at the fan-voted show at the Microsoft Theater in Los Angeles, including Green Day, Shawn Mendes, The Chainsmokers and Sting, who will also receive the American Music Award of Merit.John Legend, who will release a new album on Dec. 2, will perform, as will One Direction’s Niall Horan and Maroon 5, who recently dropped new singles. Kendrick Lamar will join Adam Levine and friends onstage.It wasn’t clear if Drake, who is the leading nominee, would attend the show, airing live on ABC at 8 p.m. Eastern. The Grammy-winning rapper broke Michael Jackson’s record for most AMA nominations after scoring 13 nominations. Drake, however, hasn’t attended many awards shows in the last few years even when he leads in nominations.The “Hotline Bling” performer will compete with himself in three categories: collaboration of the year (“One Dance” with Kyla and Wizkid, “Work” with Rihanna), favorite album – rap/hip-hop (“Views,” ”What a Time to Be Alive” with Future) and favorite song – soul/R&B (“One Dance,” ”Work”).Drake is not up for the top prize – artist of the year – where the nominees include Justin Bieber, Rihanna, Ariana Grande, Selena Gomez and Carrie Underwood. Artist of the year originally included 10 nominees, among them Drake, Beyoncé and Adele, but it was later whittled to five acts by fan voting.Rihanna, Adele, Bieber and Beyoncé also scored multiple nominations. Prince, who died earlier this year, earned a nomination for top soundtrack with “Purple Rain.” The 1984 album, which gained new attention after his death in April, will compete with “Star Wars: The Force Awakens” and “Suicide Squad: The Album.”Presenters include Taraji P. Henson, Robert Downey Jr., Zoe Saldana and Heidi Klum, while former “Saturday Night Live” comic Jay Pharaoh and model Gigi Hadid will host the show.Hadid, who hosted Canada’s iHeartRadio Much Music Awards in June, joked about changing multiple times during the live show.“Three hundred outfit changes. We’re really excited. No, I’m kidding. We’ll see. You know what, J. Lo did 10,” Hadid, 21, said of last year’s host, Jennifer Lopez. “I did five at my last award show, so maybe somewhere in between there.”Hadid is dating former One Direction member Zayn, who is nominated for new artist of the year thanks to the success of his solo album, “Mind of Mine.”Other performers Sunday night include twenty one pilots, Fifth Harmony, James Bay and Bieber, who will perform from his world tour in Zurich, Switzerland. Nicki Minaj will perform twice – alongside Grande and then with DJ Khaled, Future, Rick Ross and August Alsina.center_img Lady Gaga, Bruno Mars, Sting set for American Music Awards SHARElast_img read more

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Trump to authorize release of JFK assassination classified documents

first_img Do you see a typo or an error? Let us know. Trump to authorize release of JFK assassination classified documents (CBS) – President Trump announced on Twitter that he will allow the release of thousands of classified documents about the assassination of President John F. Kennedy after years of delays.The unexpected move means the trove of never-before-seen documents are set to be released by the National Archives by Oct. 26.Congress mandated in 1992 that all assassination documents be released within 25 years, unless the president asserts that doing so would harm intelligence, law enforcement, military operations or foreign relations. The still-secret documents include more than 3,000 that have never been seen by the public and more than 30,000 that have been released previously, but with redactions. SHARE Writer:WINK News JFK scholars believe the trove of files may provide insight into assassin Lee Harvey Oswald’s trip to Mexico City weeks before the killing, during which he visited the Soviet and Cuban embassies. Oswald’s stated reason for going was to get visas that would allow him to enter Cuba and the Soviet Union, according to the Warren Commission, the investigative body established by President Lyndon B. Johnson, but much about the trip remains unknown.Among the protected information up for release is details about the arrangements the U.S. entered into with the Mexican government that allowed it to have close surveillance of those and other embassies, said Tunheim, a federal judge in Minnesota.Kennedy experts also hope to see the full report on Oswald’s trip to Mexico City from staffers of the House committee that investigated the assassination, said Rex Bradford, president of the Mary Ferrell Foundation, which publishes assassination records. Published: October 21, 2017 9:41 AM EDT Updated: October 21, 2017 1:14 PM EDT last_img read more

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Family lawyers told to draft court orders on the day

first_imgFamily lawyers will be expected to come to court with their laptops and draft orders on the day as part of a policy drafted to reduce delays caused by growing workloads and dwindling staff resources. The court orders policy came into force at London’s Central Family Court last week.The policy, signed by His Honour Judge Robin Tolson QC, the court’s designated family judge, states that the background ‘is an environment of significantly increasing caseloads and reduced staff resources, with consequent delays in drawing up of orders by the court’.It applies to non-financial remedy cases where at least one party is represented. Court orders must be approved by judges, drawn up and handed to the parties on the day of the hearing. The judge can permit a delay but this ‘will be the exception and not the rule’.Orders must be tight in length. Legal representatives will be expected to attend court with a laptop so they can draft an order. Once agreed by all parties, the draft should be emailed to the clerk ‘while parties remain at court’.After the judge approves the order, the clerk will draw it up, print and hand it to the parties on the same day as the hearing or email the order if email addresses have been provided.If the case finishes by 1pm, the order must be lodged by 4.30pm. If the case finishes in the afternoon, the order must be lodged by 10am the next day. Cases may be listed for mention if an order is not received on time. The judge or legal adviser will draft the order on the day of the hearing for cases involving litigants in person.The policy says: ‘Judges, magistrates, legal advisers and staff at [Central Family Court] remain highly appreciative of the work done by legal professionals in the drafting of orders and are sensitive to the time which this takes up.’Barrister Ramanjit Kang, of Coram Chambers in London, told the Gazette that judges and magistrates have a statutory duty in family cases to draw up an order reflecting the court’s decision following a hearing.’It has been the convention in the family courts for a while now that the lawyers draft court orders for the court’s approval,’ she explained. ‘It is usually the lawyer for the applicant that takes the lead and produces a first draft. In cases where one party is not represented the court expects the lawyer for the represented party to produce a draft order. The process of creating a draft order is often done over email over the course of two or three days.’Kang said the policy will improve efficiency, but warned that it will extend the court day, which could affect those who have other commitments such as childcare. ‘Also, the prospect of hanging around court is inevitably going to increase costs, either to the Legal Aid Agency or a privately paying client,’ she warned.last_img read more

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Shoosmiths celebrates double-digit growth

first_imgNational firm Shoosmiths has reported an 11% rise in its net profit, as profit per equity partner continues to increase. However, the practice said it was ‘mindful’ of the challenges it now faces due to coronavirus.Net profit at Shoosmiths has increased by 11% to £42.2 million while PEP stands at £465,000, 5% more than last year. Revenue has grown 12% year-on-year to £154.2 million.Chief executive Simon Boss said: ‘These results represent another year of continued growth for Shoosmiths as we implement our strategy to become the leading UK law firm famous for its client experience.‘As Shoosmiths enters its next chapter, we are mindful of the challenges firms now face, given the advent of the unexpected public health crisis. The technologies we have invested in enabled us to adapt by rapidly to this – for example, moving our workforce to work from home over just a few days in mid-March – and we remain committed to implementing our strategy carefully as we look to the future.’Shoosmiths is one of the first firms to announce its financial results, as reporting season gets off to a slower start than normal. Magic circle firm Clifford Chance said it will publish its results in the second half of July this year, as opposed to at the start of the month.last_img read more

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